Evaluation of the relation between pleural malignant mesothelioma and asbestos exposure

Takumi Kishimoto, Keisei Okada, Toshio Sato, Tetsuya Ono, Hisao Ito
1987 The Japanese Journal of Thoracic Diseases  
Recently, the number of patients with malignant mesothelioma has increasd in Kure Kyosai Hospital. We investigated the relation between malignant mesothelioma and asbestos exposure in 8 pleural malignant mesothelioma cases after autopsy. The occupational history, indicated that 7 out of 8 patients had worked in the Japan Naval dockyard before and during World War II. The other case had a definite history of asbestos exposure. Mesotheliomas came out after 25 to more than 40 years of the first
more » ... estos exposure. When we lysed the autopsy lung tissue not involving tumor site by using sodium hypochrolite, we detected many asbestos bodies (from 522 to 149, 160) per 5g of lung tissue. These numbers are significantly (p<0.01) higher than those of non-cancer patients. Patients with more than 30,000 asbestos bodies had pleural plaques with calcification revealed in their chest X-ray. On the other hand, we analysed these asbestos bodies with a scanning electron-microscope and X-ray analyser. Most of these were composed of crocidolite or amosite, and some were chrysotile. Thus, we determined that all of these 8 patients with pleural malignant mesothelioma had been induced by asbestos exposure, especially crocidolite or amosite.
doi:10.11389/jjrs1963.25.752 fatcat:lqmisw7c7fdezlmwh4lbkwoifa