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A simple formula for determining pre-diabetes (the very early stage of diabetes mellitus) was derived from the model of Ackerman et al. [Bull Math Biophys 1965; 27: s21-37] for very smoothly varying time course patterns of blood glucose level. The natural period of blood glucose level in a healthy subject calculated using the formula was in good agreement with the value obtained by computer work.doi:10.2174/1876524600902010029 fatcat:v4tnrxskqjbktbypaprqeslvey