SAT0119 Physical activity in tunisian adults with rheumatoid arthritis

A. feki, A. fazaa, S. miladi, K. ouenniche, S. kassab, S. chekili, K. ben abdelghani, A. laatar
2018 Saturday, 16 JUNE 2018   unpublished
responders (p<0.001 and p<0.001 respectively), nevertheless, non-responders showed a rising trend (p=0.086 and p=0.051 respectively). Binary logistic regression model revealed that baseline serum sICAM-1 levels had a positive effect on response to therapy. ROC curve analysis for predictive ability of baseline serum sICAM-1 showed an area under the curve (AUC) of 0.775 (p=0.010). Conclusions: Serum sICAM-1 and CXCL13 levels were elevated in RA patients, and they were higher in seropositive
more » ... seropositive patients than in seronegative patients. Elevated baseline serum sICAM-1 levels were associated with favorable response to TNF-α inhibitor therapy. The decrease of serum sICAM-1 levels after treatment in responders was consistent with their therapeutic response. Thus, baseline serum sICAM-1 could be a predictive biomarker for TNF-α inhibitor therapy in RA patients. There was a lack of reliable evidence that baseline serum CXCL13 had predictive ability, possibly due to different mechanisms of action or small sample size. REFERENCES : [1] Zampeli E, Vlachoyiannopoulos PG, Tzioufas AG. Treatment of rheumatoid arthritis: Unraveling the conundrum[J]. J Autoimmun 2015;65:1-18. [2] Smolen JS, Aletaha D. Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges[J]. Nat Rev Rheumatol 2015;11(5):276-89. [3] Lindstrom TM, Robinson WH. Biomarkers for rheumatoid arthritis: making it personal[J]. Scand J Clin Lab Invest Suppl, 2010;242:79-84.
doi:10.1136/annrheumdis-2018-eular.4702 fatcat:zy6mon4p5bbu7jbyonwmozcety