Inhibitors of Nitric Oxide Production from the Flowers of Angelica furcijuga: Structures of Hyuganosides IV and V

Hisashi Matsuda, Toshio Morikawa, Teruki Ohgushi, Tomoko Ishiwada, Norihisa Nishida, Masayuki Yoshikawa
2005 Chemical and pharmaceutical bulletin  
The methanolic extract from the flowers of Angelica furcijuga KITAGAWA was found to inhibit nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages. From the methanolic extract, two new glycosides, hyuganosides IV and V, were isolated together with 28 known constituents. The structures of the new constituents were determined on the basis of chemical and physicochemical evidence. Furthermore, the inhibitory effects of 11 coumarin constituents on nitric oxide
more » ... n were examined. Among them, 3-angeloyl-cis-khellactone (IC 50 ‫28؍‬ m mM), (S)-(؊)-oxypeucedanin (57 m mM), imperatorin (60 m mM), isoepoxypteryxin (53 m mM), and isopteryxin (8.8 m mM) showed inhibitory activity.
doi:10.1248/cpb.53.387 pmid:15802837 fatcat:qxpkqzrm65bste724g6wxj7eiu