Piperazine catalyzed convenient synthesis of 4H-pyran derivatives from α,α′-bis(substituted-benzylidene) cycloalkanones and malononitrile under reflux conditions

Akbar Mobinikhaledi, Naser Foroughifar, Hassan Moghanian, Nahid Keshavarzi
2015 Journal of Saudi Chemical Society  
A facile, simple and convenient method for the synthesis of 4H-pyran derivatives has been achieved through the condensation reactions of a,a 0 -bis(substituted-benzylidene) cycloalkanones and malononitrile in the presence of piperazine as an odorless and easy to work catalyst under reflux conditions. With the optimized reaction conditions, the desired products were obtained with 62-82% yields. ª 2012 Production and hosting by Elsevier B.V. on behalf of King Saud University.
doi:10.1016/j.jscs.2012.05.001 fatcat:6p3krciqqjchbklrw4xaebx22y