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The aim of our study is to compare the power of two different approaches to detect passive genotype-environment covariance originating from simultaneous cultural and genetic transmission. In the traditional Nuclear Twin Family Design cultural transmission is estimated on the basis of the phenotypic covariance matrices of the mono- and dizygotic twins and their parents, where phenotyping is required in all family members. A more recent method is the Transmitted-Nontransmitted allele design,doi:10.1101/2020.09.07.285817 fatcat:imml5l5jtvbkvdr5x3kvjwglre