Epilepsy is the most common presentation in a neurological setting and stands next to stroke and dementia in its prevalence. Epilepsy is the paroxysmal, transitory disturbance of brain function. The aim of this study was to assess the efficacy of the Panchagavya Ghrita administered after Virechana Karma in the management of Apasmara (epilepsy) with special reference to frequency, duration and severity of attack. This study was a single arm interventional study with pre and post test design at

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... tpatient and inpatient level in a tertiary Ayurveda hospital attached to teaching institute located in district headquarters in Southern India. 30 patients of epilepsy were selected from the OPD and IPD of SDM College of Ayurveda and Hospital, Hassan, Karnataka, India fulfilling the inclusion criteria underwent Virechana after the attainment of Nirama Lakshana followed by Samyak Snigdha Lakshana with Panchagavya Ghrita. Thereafter Samsarjana karma was followed according to the Shuddhi. For Shamana 15 ml of Panchagavya Ghrita twice a day with warm water before food was administered for 2 months. The effectiveness of the treatment was considered positive based on the studies and observations. Virechana showed significant relief in frequency, duration and severity of attack. After Shamana, sustained relief was seen in the patients. The result proved the efficacy of Panchagavya Ghrita and Virechana Karma in the management of Apasmara.