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We reported previously that a proportion of natural CD25 + cells isolated from the PBMC of HCV patients can further upregulate CD25 expression in response to HCV peptide stimulation in vitro, and proposed that virus-specific regulatory T cells (Treg) were primed and expanded during the disease. Here we describe epigenetic analysis of the FOXP3 locus in HCVresponsive natural CD25 + cells and show that these cells are not activated conventional T cells expressing FOXP3, but hardwired Treg with adoi:10.1371/annotation/523d94fe-9730-499b-95b1-addd94089ff8 fatcat:s2zya7wcsnehxc4j5tk55wkqhy