ELICITATION ANTIBODIES OF IgG TO HELICOBACTER PYLORI INFECTION AND THE FREQUENCY PREVALENCE AMONG PATIENTS MULTIPLE MYELOMA AND POTENTIAL DONORS OF HEMATOPOIETIC STEM CELLS

D.A. Baratova, Baratova M.А., S.K. Zhusupova
2022 Zenodo  
The article presents the results of studies using an invasive method for diagnosing the levels of antibodies IgG to H.pylori infection among patients multiple myeloma residents of Kirgizia in collation with donors of hematopoietic stem cells. In patients with MM of the kirgiz nationality, negative in 39% of cases and less often low, medium, high levels of IgG antibodies to H. pylori infection are detected in comparison with patients with MM of the Russianspeaking population of Kirgizia.At
more » ... ative assessment of indicators of patients with MM of the kirgiz nationality elicitation negative levels antibodies of IgG to H. pylori infection in 20% of cases and in potential donors of hematopoietic stem cells in 80% of cases. Among patients MM of the Russian-speaking population of Kirgizia have elicitation negative levels antibodies of IgG to H.pylori infection in 63% of cases and low in 70% of cases by compared with healthy residents of the North-West region of the Russian Federation. A study at for the first time elicitation patients MM definition on antibodies for IgG to H. pylori infection makes it possible to early diagnose H.pylori infection and recognize pathology of the gastrointestinal tract (atrophic, erosive, erosive- ulcerative gastritis, steroid ulcers, gastric and duodenal ulcers), where inevitable transfer of tableted steroid drugs on intravenous administration, as well as in parallel with basic targeted therapy, in combination antibiotic therapy with H2-blockers, proton pump inhibitors, antacids. In this connection according to indications, timely push aside patients with MM from bone marrow autotransplantation and dismissal potential donors from donation of haploidentical (brother, sister), closely related, unrelated hematopoietic stem cell transplantation. When remission is achieved, patients with MM should, according to indications, carry out standard eradication therapy in combination with bacterial strains. Thus, in oncohematological diseases, these studies at the present stage, the detection of H [...]
doi:10.5281/zenodo.7244041 fatcat:32stqst7sbhpncktcdkmqxajo4