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Determining the different conformational states of a protein and the transition paths between them is key to fully understanding the relationship between biomolecular structure and function. This can be accomplished by sampling protein conformational space with molecular simulation methodologies. Despite advances in computing hardware and sampling techniques, simulations always yield a discretized representation of this space, with transition states undersampled proportionally to theirarXiv:1910.04543v2 fatcat:wcyqatq3cbhczdku5r2wwkkeqa