Simulation Model of Trabecular Bone Remodeling Considering Effects of Osteocyte Apoptosis and Targeted Remodeling

Jiyean KWON, Hisashi NAITO, Takeshi MATSUMOTO, Masao TANAKA
2010 Journal of Biomechanical Science and Engineering  
Bone structure is renewed or restructured in part by a load-dependent remodeling. In this study, a mathematical model of bone surface remodeling over a wide range of strain was established. We assumed that in a low strain range, bone resorption occurs at an accelerated rate with strain decrease owing to low strain-induced osteocyte apoptosis, and that in a high strain range, bone formation occurs at an accelerated rate with strain increase (targeted remodeling). In a physiological strain range,
more » ... bone formation or resorption was assumed to occur stochastically according to the degree of local stress non-uniformity. The utility of the present model was examined through three-dimensional numerical simulation of femoral trabecular architecture. 540 windows were considered by referring to the mechanostat theory (2) : disuse window (DW) and overuse window (OW) in addition to physiological window (PW). Different balances between bone resorption and formation were assigned for each window. That is, physiological bone resorption and formation based on local stress non-uniformity (6) ~ (10) for PW; resorption dominant change by osteocyte decrease/apoptosis for DW; and formation dominant change by targeted remodeling for OW. The utility of the present model was examined by applying it to numerical simulation of trabecular architecture in human femurs.
doi:10.1299/jbse.5.539 fatcat:434iycwdnbdozhqqcmer3kl5gu