Because of their low cost, parabens are extensively employed as preservatives in a variety of cosmetics applied to the underarm and breast area.Aim of the work: This study was done to evaluate the Uterine, Ovarian, and Mammary toxicities of parabens. Materials and methods: Fifty adult female rats were used and given paraben orally for six months at parabens at dose of 10 % of the LD50 equal to 4.6mg\kg.bw and at dose of 40 % of the LD50 equal to 18.4 mg\kg.bw. Mushroom was given orally to at

more »

... e of 10 mg/kg/day for six months too. Results: Oral administration of BP induced biochemical and histopathological changes. Biochemically: BP toxicity manifested by changes in the uterine, ovarian and mammary function tests manifested by increase expression of alpha estrogenic receptors , in addition to significant increase in MDA level in gp.2 in comparison to gp.1 in all tissues , Also non-significant increase in TAC and GSH in gp.2 in comparison to gp.1 in ovarian and mammary tissue, while in uterine tissue non-significant decrease in TAC and GSH in gp.2 in comparison to gp.1 . Giving mushroom caused amelioration to the Uterine, Ovarian, and Mammary toxicities by inducing recovery in Uterine, Ovarian, and Mammary functions in comparison to paraben treated group. For histopathological findings: BP induced hyperplasia in epithelial lining of the endometrium and the endometrial gland, mild inflammatory reaction in the theca granulosa in the mature follicles mainly neutrophils which improved after mushroom treatment. Conclusion: BP induced Uterine, Ovarian, and Mammary toxicities which improved by mushroom treatment.