Vitiligo is a chronic acquired disorder characterized by the development of depigmented macules which slowly enlarges with the concurrent appearance of new lesions. Aim: The aim is to study the efficacy of treating vitiligo by microneedling followed by application of 5-fluorouracil on vitiligo patches. Materials and Methods: This study was conducted in a tertiary hospital from March 2019 to August 2019. For this study, we selected about 50 patients in the age group of 10-50 years who had been

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... king treatment for vitiligo for 2-3 years without much improvement. We suggested them about needling with 5-fluorouracil application over vitiligo patches. The procedure was performed at a gap of 2 weeks on vitiligo patches of various patients for about 3 months. Result: After about 1 month of this procedure, we noticed an improvement in about 40% of patients with some erythema and hyperpigmentation developing on the margins of vitiligo patches. Gradually more than 50% of patients had similar improvement by the end of 2 months. After 3 months, about 60% of patients had hyperpigmentation in the vitiligo lesions with almost complete pigmentation in very small patches; larger ones had less pigmentation and 40% did not have any pigmentation from the previous state. Conclusion: 5-fluorouracil is a simple and effective method for treating small vitiligo patches (< 5 cm diameter generally) with no major side effects. It is a cost-effective procedure in treating a very resistant disease, i.e., vitiligo, especially for small lesions.