Original Article Association between MCP-1 A2518G polymorphism and coronary artery disease risk: evidence from 21 case-control studies

Jianyuan Pan, Chao Gao
2016 Int J Clin Exp Med   unpublished
The MCP-1 A2518G polymorphism has been indicated to be correlated with coronary artery disease (CAD) susceptibility, but the results of studies are still debatable. Thus, a meta-analysis was carried out. The databases of PubMed, Embase, Web of Science, and CNKI (China National Knowledge Infrastructure) were searched. The related data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. At last, 21 case-control studies with 8,480 cases and 1,2366
more » ... ls were included in this meta-analysis. Overall, the significant association was showed (G allele vs. A allele: OR = 1.11, 95% CI: 1.02-1.21, P = 0.000; AG + GG vs. AA: OR = 1.14, 95% CI: 1.01-1.29, P = 0.000) between MCP-1 A2518G polymorphism and CAD risk. However, the evidence of heterogeneity was found among the investigated studies, and subgroup analyses were conducted according to source of population in control, ethnicity, types of CAD end points, and status of HWE. In conclusion, the meta-analysis suggests the MCP-1 A2518G polymorphism (AG + GG genotypes) is a risk factor for CAD. Further large-scale and well-designed studies are still needed to confirm the results of our meta-analysis.