Functional roles of NKT cell in the immune system

Ken-ichiro Seino
2004 Frontiers in Bioscience  
CD1d-restricted Natural Killer T cells (NKT cells), a novel lymphocyte lineage, are considered to play an intermediary role bridging innate and acquired immunity. This review discusses the characteristics of NKT cells and their biological significance in the immune system, and summarizes their in vivo functions observed in a number of pathological settings, including infectious diseases, cancer, autoimmunity, and transplantation. Further, we discuss recent data that have generated considerable
more » ... rated considerable interest in utilizing NKT cells as targets of new therapeutic interventions in various human diseases.
doi:10.2741/1418 pmid:15358582 fatcat:4tw2igvcarcedpmwy6cpu3veyu