Antibiotic Use and the Risk of Lung Cancer

H. Zhang, L. A. Garcia Rodriguez, S. Hernandez-Diaz
2008 Cancer Epidemiology, Biomarkers and Prevention  
Antibiotic use has been associated with an increased risk of cancer in epidemiologic studies. We evaluated the association between antibiotic use and the risk of primary lung cancer by conducting a prospective casecontrol study nested in a cohort of subjects who were 40 to 84 years old in 1995 to 2004, with at least 2 years of enrollment in The Health Improvement Network. There were 4,336 cases of primary lung cancer. A random sample of 10,000 controls was frequency matched to the cases for
more » ... sex, and calendar year of diagnosis. Antibiotic exposure was measured by the total number of antibiotic prescriptions and the cumulative number of days on antibiotics since enrollment. We discounted exposure 1 year before the date of cancer diagnosis. Relative risks (RR) and 95% confidence intervals (95% CI) were estimated using conditional logistic regres- Materials and Methods We conducted a nested case-control study within a population-based cohort using computerized medical record information from the THIN database in the United Kingdom (11, 12) . THIN collects data on around Cancer Epidemiol Biomarkers Prev
doi:10.1158/1055-9965.epi-07-2817 pmid:18544646 fatcat:rlrnr7jtpjd3zpitdfzzforwzm