The modulatory capacity of interleukin-21 in the pathogenesis of autoimmune disease

Alexis Vogelzang
2008 Frontiers in Bioscience  
In this review, we discuss recent progress from studies on the biology of IL-21 and the role of this cytokine in the pathogenesis of autoimmunity. Recent studies have demonstrated that IL-21 plays an important and nonredundant role in a number of autoimmune animal models indicating that IL-21 could be a common modulator of the adaptive immune response towards self-tissue constituents in diseases such as systemic lupus erythematosus, models of rheumatoid arthritis, multiple sclerosis and type-1
more » ... lerosis and type-1 diabetes. Also, the studies on the production of IL-21 in human autoimmune diseases and its behaviour on human cells in vitro are revealing the potential of IL-21 to exacerbate cellular processes that determine the course of autoimmune diseases.
doi:10.2741/3082 pmid:18508588 fatcat:ny76im76sbhhnowvn6nl5n4mee