Reproducibility of hippocampal atrophy rates measured with manual, FreeSurfer, AdaBoost, FSL/FIRST and the MAPS-HBSI methods in Alzheimer's disease

Keith S. Cover, Ronald A. van Schijndel, Adriaan Versteeg, Kelvin K. Leung, Emma R. Mulder, Remko A. Jong, Peter J. Visser, Alberto Redolfi, Jerome Revillard, Baptiste Grenier, David Manset, Soheil Damangir (+5 others)
2016 Psychiatry Research : Neuroimaging  
 Compared the reproducibility of methods for measuring hippocampal atrophy rates  Compared FreeSurfer, FSL/FIRST, MAPS-HBSI, AdaBoost and manual  Back-to-back MPRAGEs at baseline and year one for N=562 ADNI1 1.5T subjects  Used a novel but simple statistical test that is robust to outlying data points  MAPS-HBSI should require half the subjects in a clinical trial than others tested *Highlights Abstract The purpose of this study is to assess the reproducibility of hippocampal atrophy rate
more » ... easurements of commonly used fully-automated algorithms in Alzheimer disease (AD). The reproducibility of hippocampal atrophy rate for FSL/FIRST, AdaBoost, FreeSurfer, MAPS independently and MAPS combined with the boundary shift integral (MAPS-HBSI) were calculated. Back-to-back (BTB) 3D T1-weighted MPRAGE MRI from the Alzheimer's Disease Neuroimaging Initiative (ADNI1) study at baseline and year one were used. Analysis on 3 groups of subjects was performed -562 subjects at 1.5T, a 75 subject group that also had manual segmentation and 111 subjects at 3T. A simple and novel statistical test based on the binomial distribution was used that handled outlying data points robustly. Median hippocampal atrophy rates were -1.1% /year for healthy controls, -3.0%/year for mildly cognitively impaired and -5.1% /year for AD subjects. The best reproducibility was observed for MAPS-HBSI (1.3%), while the other methods tested had reproducibilities at least 50% higher at 1.5T and 3T which was statistically signifigant. For a clinical trial, MAPS-HBSI should require less than half the subjects of the other methods tested. All methods had good accuracy versus manual segmentation. The MAPS-HBSI method has substantially better reproducibility than the other methods considered.
doi:10.1016/j.pscychresns.2016.04.006 pmid:27179313 fatcat:czuhtwha2rb7doxpmvy72ggm5e