Retinal Vascular Caliber Changes on OCT after Intravitreal Bevacizumab Injection in Diabetic Macular Edema

Young Jun Kim, Hyoung Eun Kim, Won Kyung Song, Sung Soo Kim
2012 Journal of the Korean Ophthalmological Society  
연세대학교 의과대학 안과학교실 1 , 포천중문의과대학교 분당차병원 안과학교실 2 목적: 빛간섭단층촬영(OCT)을 이용하여 당뇨황반부종 환자에서 안내 베바시주맙(Bevacizumab) 주사 후 망막 혈관 직경의 변화를 알 아보았다. 대상과 방법: 당뇨황반부종으로 1.25 mg/0.05 ml 안내 베바시주맙 주사를 받은 환자 29명, 34안을 대상으로 하였으며 주사를 시행한 눈의 반대안 24안을 대조군으로 하였다. 주사 전, 주사 후 1개월 및 3개월에 빛간섭단층촬영을 이용하여 중심황반두께 및 망막 혈관의 직경을 0.5-1유두직경 떨어진 동일한 지점에서 측정하였다. Purpose: To investigate retinal vascular caliber changes with Spectral Domain OCT after intravitreal bevacizumab injection in diabetic macular edema patients Methods: Thirty-four
more » ... s of 29 diabetic macular edema patients who were intravitreously injected with bevacizumab (1.25 g/0.05 ml) were studied. Twenty-four fellow eyes of 24 patients with bevacizumab injection were also recruited as a control group. We measured retinal vascular caliber a distance of 0.5-1 disc sizes from the disc margin with Spectral Domain OCT at baseline and 1-month and 3-month follow-up visits. Central macular thicknesses were also measured. Results: Over the 3 months of study, there was a significant reduction of arteriolar caliber compared to baseline (p = 0.024), There was significant reduction of venular caliber at 1 month (p = 0.001) and 3 months (p = 0.000) compared to baseline. Venular caliber reduction at the 3-month follow-up was significantly correlated with central macular thickness (R = 0.487, p = 0.003). Conclusions: Retinal venular caliber reduction was significant at 1-and 3-month follow-up, and arteriolar caliber reduction was significant at 3-month follow-up compared to baseline. After 3 months of treatment, venular caliber reduction was correlated with reduction of central macular thickness. J Korean Ophthalmol Soc 2012;53(2):262-267
doi:10.3341/jkos.2012.53.2.262 fatcat:7v7zjhforncctg4nw3qd55ukbe