Perinatal respiratory infections and long term consequences From the womb to the adult How to cite

Luciana Indinnimeo, Valentina De Vittori, Vassilios Fanos, Michele Mussap, Antonio Del Vecchio, Bo Sun, Shanghai
2015 Journal of Pediatric and Neonatal Individualized Medicine   unpublished
Respiratory syncytial virus (RSV) is the most important pathogen in the etiology of respiratory infections in early life. 50% of children are affected by RSV within the first year of age, and almost all children become infected within two years. Numerous retrospective and prospective studies linking RSV and chronic respiratory morbidity show that RSV bronchiolitis in infancy is followed by recurrent wheezing after the acute episod. According to some authors a greater risk of wheezing in
more » ... with a history of RSV bronchiolitis would be limited to childhood, while according to others this risk would be extended into adolescence and adulthood. To explain the relationship between RSV infection and the development of bronchial asthma or the clinical pathogenetic patterns related to a state of bronchial hyperreactivity, it has been suggested that RSV may cause alterations in the response of the immune system (immunogenic hypothesis), activating directly mast cells and basophils and changing the pattern of differentiation of immune cells present in the bronchial tree as receptors and inflammatory cytokines. It was also suggested that RSV infection can cause bronchial hyperreactivity altering nervous airway modulation, acting on nerve fibers present in the airways (neurogenic hypothesis). The benefits of passive immunoprophylaxis with palivizumab, which seems to represent an effective approach in reducing the sequelae of RSV infection Proceedings 2/5 Journal of Pediatric and Neonatal Individualized Medicine • vol. 4 • n. 2 • 2015 www.jpnim.com Open Access Indinnimeo • De Vittori in the short-and long-term period, strengthen the implementation of prevention programs with this drug, as recommended by the national guidelines of the Italian Society of Neonatology.
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