EFFECT OF SOME DRUGS AND HERBS ON EXPERIMENTAL RATS SUFFERING FROM OBESITY

عبد الکريم ابراهيم الحسين, فاروق محمد التلاوى, عطيات محمد البهى, عبد الرحمن محمد عطية, أشرف عبد العزيز عبد المجيد
2011 مجلة بحوث التربية النوعية  
‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ J J J J ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ -٢٠ ٢٠ ٢٠ ٢٠١١ ١١ ١١ ١١ Abstract The present study investigated the effect of some drugs (Orlistat and Chitosan) and herbs (Neopuntia and Jamu Tea) on weight, lipid fractions, glucose, liver function and kidney functions of obese rats fed on high fat diet. Healthy male albino rats weighing (200±5 g) were divided
more » ... 5 g) were divided into two main groups. The first group (n = 6) fed on a basal diet B.D., while the second main group 30 rat were fed for 6 weeks on high fat diet to induce the obesity in rats. After these period, rats were divided into 5 subgroups (n =6). As a following: Subgroup (1) fed on high fat and high protein diet (20% fat and 20% protein) as a positive control. Subgroup (2) fed on high fat and high protein diet and treated daily with 5 mg orlistat/ rat. Subgroup (3) fed on high fat and high protein diet and treated daily with 5 mg chitosan/ rat. Subgroup (4) fed on high fat and high protein diet and treated daily with 5 mg Neopuntia / rat. Subgroup (5) fed on high fat and high protein diet and treated daily with 5 ml Jamu tea / rat. Body weight was decreased in all treated groups. All parameters of lipid profile (cholesterol, triglycerides, HDL-c, LDL-c and VLDL-c), liver function (AST & ALT enzymes), glucose and kidney functions improved with treated the obese rats with Orlistat , Chitosan , Neopuntia and Jamu Tea, especially when using 5 mg orlistat/ rat followed by 5 mg chitosan / rat, and other herbs (Neopuntia and Jamu Tea), respectively . It was concluded that, treating obese rats which fed on high fat and high protein diet with Orlistat , Chitosan , Neopuntia and Jamu Tea decreased the weight of obese rats and improved the body functions. Introduction: Over the past 20 years obesity has become a worldwide concern of frightening proportion. The World Health Organization estimates that there are over 400 million obese and over 1.6 billion overweight adults, a figure which is projected to almost double by 2015. This is not a disease restricted to adults -at least 20 million children under the age of 5 years were overweight in 2005(WHO, 2006). Obesity is a major public health concern because it increases the risk for many chronic conditions, such as cardiovascular diseases, diabetes, hypertension, coronary artery disease, and cancer ( Zhang &Reisin 2000; Lyznicki et al., 2001 and Calle et al., 2003). ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ J J J J ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ -٢٠ ٢٠ ٢٠ ٢٠١١ ١١ ١١ ١١ people increases the amount of weight lost in a 6-month weight-loss program (by 3.8 kg), compared with a high-carbohydrate diet by enhancing satiety (Skov et al., 1999) . A higher protein intake during weight loss may also prevent some of the inevitable loss of lean body mass and, thus, may enhance insulin sensitivity (Baba et al., 1999) . ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ J J J J ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ -٢٠ ٢٠ ٢٠ ٢٠١١ ١١ ١١ ١١ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ J J J J ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ -٢٠ ٢٠ ٢٠ ٢٠١١ ١١ ١١ ١١ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ J J J J ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ -٢٠ ٢٠ ٢٠ ٢٠١١ ١١ ١١ ١١ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ J J J J ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ -٢٠ ٢٠ ٢٠ ٢٠١١ ١١ ١١ ١١ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ J J J J ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ -٢٠ ٢٠ ٢٠ ٢٠١١ ١١ ١١ ١١ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ J J J J ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ -٢٠ ٢٠ ٢٠ ٢٠١١ ١١ ١١ ١١ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ J J J J ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ -٢٠ ٢٠ ٢٠ ٢٠١١ ١١ ١١ ١١ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ J J J J ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ -٢٠ ٢٠ ٢٠ ٢٠١١ ١١ ١١ ١١ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ J J J J ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ -٢٠ ٢٠ ٢٠ ٢٠١١ ١١ ١١ ١١ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ J J J J ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ -٢٠ ٢٠ ٢٠ ٢٠١١ ١١ ١١ ١١ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ ‫א‬ Ø ‫א‬ ę ġ J J J J ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫د‬ ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫و‬ ‫د‬ ğ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ ‫ون‬ ‫א‬ -٢٠ ٢٠ ٢٠ ٢٠١١ ١١ ١١ ١١ ‫ﺑﺎﻟﺴﻤﻨﺔ‬ ‫ﺍﳌﺼﺎﺑﺔ‬ ‫ﺍﻟﺘﺠﺎﺭﺏ‬ ‫ﻓﺌﺮﺍﻥ‬ ‫ﻋﻠﻲ‬ ‫ﻭﺍﻻﻋﺸﺎﺏ‬ ‫ﺍﻻﺩﻭﻳﺔ‬ ‫ﺑﻌﺾ‬ ‫ﺗﺄﺛﲑ‬ ‫و‬ ‫א‬ ‫وق‬ ‫و‬ ‫א‬ ‫وق‬ ‫و‬ ‫א‬ ‫وق‬ ‫و‬ ‫א‬ ‫وق‬ GG GG GG GG J J J J ‫א‬ ª ‫א‬ ª ‫א‬ ª
doi:10.21608/mbse.2011.145163 fatcat:v7zx42ck35cdllflfiwakqmbzm