The densest distribution of somatostatin (SRIF) neuron perikarya is localized in the hypothalamic periventricular nucleus (Pe) close to the third ventricle, from which many fibers are projected to the median eminence. The release of SRIF in the neurohemal organ distributed in many periventricular structures in the lateral and third ventricles. These 第68巻 第5号 508 視床 下 部 ソマ トス タチ ンの生理 機 能(鈴 木) findings suggest that SRIF produced in the Pe neurons is transported to other brain areas via

more »

... al fluid in addition to neuronal connections for modulating the activity of neurons which have SRIF receptors. Thus, hypothalamic Pe SRIF neurons have dualistic roles for controlling anterior pituitary function and modulating CNS neuron activity.