Pleiotropic effect of vitamin D in cystic fibrosis

Teresa Grzelak, Klaudia Mikołajczyk
2015 Advances in Respiratory Medicine  
Cystic fibrosis (CF) is the most common recessively autosomally inherited disorder in the Caucasian population. It is incurable, multi -systemic disease with progressive course. CF is caused by CFTR gene mutation, the product of which is Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). CF patients are exposed to fat-soluble vitamins deficiency, including vitamin D. It is related to fat malabsorption (caused by exacerbation exocrine pancreatic insufficiency), decreased sun exposure
more » ... used by receiving antibiotics photophobia), reduction of adipose tissue and insufficient supply with food. The discovery of vitamin D receptor (VDR) presence outside the skeletal system allowed to conclude that vitamin D is responsible not only for mineral economy, but also for immunological processes, respiratory status, intestinal microflora and cystic fibrosis-related diabetes (CFRD) course. Basing on literature data, it is suggested that vitamin D plays an important role in the prevention of diseases coexisting with CF. The right dosage of vitamin D allows to maintain a better lung function and prevent chronic pulmonary infections. It has also been shown that normal levels of vitamin D may be important in increasing the chances of successful lung transplant surgery. Taking the wide spectrum of vitamin D effects into account, it is recommended to maintain serum concentrations above the minimum in patients with CF. In summary, maintaining the proper vitamin D levels in patients with CF is important because of its pleiotropic effect. It can be achieved through regular monitoring of vitamin D levels and individual supplementary dose for each patient.
doi:10.5603/arm.a2018.0029 pmid:30110122 fatcat:mt6ld7m2eval5dn3sgxnqhogly