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Caveolin-1 Expression Negatively Regulates Cell Cycle Progression by Inducing G0/G1 Arrest via a p53/p21WAF1/Cip1-dependent Mechanism
2001
Molecular Biology of the Cell
Caveolin-1 is a principal component of caveolae membranes in vivo. Caveolin-1 mRNA and protein expression are lost or reduced during cell transformation by activated oncogenes. Interestingly, the human caveolin-1 gene is localized to a suspected tumor suppressor locus (7q31.1). However, it remains unknown whether caveolin-1 plays any role in regulating cell cycle progression. Here, we directly demonstrate that caveolin-1 expression arrests cells in the G 0 /G 1 phase of the cell cycle. We show
doi:10.1091/mbc.12.8.2229
pmid:11514613
pmcid:PMC58591
fatcat:gr2sqqivljhbtl754n56rmf4sm