Structure-Based Virtual Screening of Benzaldehyde Thiosemicarbazone Derivatives against DNA Gyrase B of Mycobacterium tuberculosis

Andiyappan Kistan, Balakrishnan Anna Benedict, Sundaramoorthy Vasanthan, Alphonse PremKumar, Malathi Kullappan, Jenifer Mallavarpu Ambrose, Vishnu Priya Veeraraghavan, Gayathri Rengasamy, Krishna Mohan Surapaneni, Saravanan Ramachandran
2021 Evidence-Based Complementary and Alternative Medicine  
Emergence of antibiotic-resistant Mycobacterium tuberculosis (M. tuberculosis) restricts the availability of drugs for the treatment of tuberculosis, which leads to the increased morbidity and mortality of the disease worldwide. There are many intrinsic and extrinsic factors that have been reported for the resistance mechanism. To overcome such mechanisms, chemically synthesized benzaldehyde thiosemicarbazone derivatives were screened against M. tuberculosis to find potential inhibitor for
more » ... culosis. Such filtering process resulted in compound 13, compound 21, and compound 20 as the best binding energy compounds against DNA gyrase B, an important protein in the replication process. The ADMET prediction has shown the oral bioavailability of the novel compounds.
doi:10.1155/2021/6140378 pmid:34938343 pmcid:PMC8687812 fatcat:x2un2hsg4nglpnjb5pah4j55lq