The work presented below, aimed at studying the onset, development and manifestations of pathomorphic chondropathy in acute and subchronic experimental exposure of opioid analgesics. The objective was achieved by using microscopic visualization technique of cellular components of the articular cartilage. To obtain the microstructural materials we applied generally accepted, conventional methods.The results of the study in the future will allow to form a pathomorphological basis, which can be

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... d for a comparative characterization of the structural components of the articular cartilage of the knee joint in the early and late stages (acute and subchronic) of experimental opioid exposure.