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The Platelet Activity After Clopidogrel Termination (PACT) Study
2010
Circulation. Cardiovascular Interventions
Background-"Rebound" platelet hyperreactivity after discontinuation of clopidogrel has been proposed to lead to increased thrombotic risk, including late stent thrombosis. However the hypothesis that discontinuation of clopidogrel results in platelet hyperreactivity has never been rigorously tested. We therefore performed a randomized, double-blind, placebo-controlled, crossover study: the Platelet Activity after Clopidogrel Termination (PACT) study. Methods and Results-Platelet reactivity in
doi:10.1161/circinterventions.110.937961
pmid:20736449
fatcat:wbzhg4natrdczd53pjaa7w6jce