Chemo-Preventive Action of Resveratrol: Suppression of p53—A Molecular Targeting Approach

Rokeya Akter, Md. Habibur Rahman, Deepak Kaushik, Vineet Mittal, Diana Uivarosan, Aurelia Cristina Nechifor, Tapan Behl, Chenmala Karthika, Manuela Stoicescu, Mihai Alexandru Munteanu, Cristiana Bustea, Simona Bungau
2021 Molecules  
Extensive experimental, clinical, and epidemiological evidence has explained and proven that products of natural origin are significantly important in preventing and/or ameliorating various disorders, including different types of cancer that researchers are extremely focused on. Among these studies on natural active substances, one can distinguish the emphasis on resveratrol and its properties, especially the potential anticancer role. Resveratrol is a natural product proven for its therapeutic
more » ... activity, with remarkable anti-inflammatory properties. Various other benefits/actions have also been reported, such as cardioprotective, anti-ageing, antioxidant, etc. and its rapid digestion/absorption as well. This review aims to collect and present the latest published studies on resveratrol and its impact on cancer prevention, molecular signals (especially p53 protein participation), and its therapeutic prospects. The most recent information regarding the healing action of resveratrol is presented and concentrated to create an updated database focused on this topic presented above.
doi:10.3390/molecules26175325 pmid:34500758 pmcid:PMC8433711 fatcat:6miexemuubdmhga46g2ysmn6je