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Study objective. To study the efficacy of folic acid drugs, in particular metafolin, at the stage of pregravid preparation and during pregnancy to prevent congenital malformations and complications of pregnancy.Material and methods. We conducted a search of the literature sources by the keywords «folic acid», «folates», «metafolin», «pregnancy», «methyltetrahydrofolate» in domestic and foreign databases: elibrary, Medline/PubMed, Embase, CINAHL. 23 sources were selected.Study results. One ofdoi:10.21518/2079-701x-2017-2-48-50 fatcat:d2niabyjozaijgefm5e7hnyqbi