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This research manuscript describes simple, sensitive, precise, accurate, economic reverse phase high performanceliquid chromatography method for the simultaneous determination of Betahistine Dihydrochloride (BET) and Prochlorperazine Maleate (PRO) in Tablet dosage form. The sample was analyzed by reverse phase C18 column (X terra C18, 150 mm × 4.6 mm, 5µm) asstationary phase; acetonitrile : methanol : phosphate buffer PH 4 (45 : 45 : 10 , v/v/v) as a mobile phase at a flow rate of 0.8 ml/min.fatcat:3hv7az5w2vdshaj6iupnnjfdey