Congenital adrenal hyperplasia (CAH), non-classic form (with delayed debut) is the second cause of hyperandrogenism with a prevalence of 1,4-4%. The aim of the study was to establish the frequency of main hyperandrogenic manifestation in a group of women diagnosed with non-classic form of CAH. The study was performed on 41 patients diagnosed with non-classic form of CAH through the measurement of 17-hydroxyprogesterone and ACTH test. The following frequency was observed: hirsutism 85%,

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... dysfunction 56%, seborrheic syndrome 53%, alopecia 27%, and obesity 46%. Keywords: congenital adrenal hyperplasia, hyperandrogenic manifestation. Rezumat: Hiperplazia adrenală congenitală (HAC), forma neclasică (cu debut tardiv) este considerată a doua cauză de hiperandrogenism, cu o prevalenţă de 1,4-4%. Scopul studiului a fost determinarea frecvenţei principalelor manifestări hiperandrogenice la un lot de femei diagnosticate cu forma neclasică a HAC. Studiul a fost realizat pe un număr de 41 de cazuri diagnosticate cu forma neclasică a HAC, prin dozarea 17-hidroxiprogesteronului şi a testului la ACTH. A fost întâlnită următoarea frecvenţă: hirsutismul 85%, disfuncţia ovulatorie 56%, sindromul seboreic 53%, alopecia 27%, supraponderea şi obezitatea 46%. Cuvinte cheie: hiperplazia adrenală congenitală, manifestări hiperandrogenice INTRODUCTION The main hyperandrogenic manifestations (hirsutism, alopecia, ovulatory dysfunction, acne) are important criteria of addressability, both in the medical specialities (endocrinology, dermatology, plastic surgery, gynecology), as well in paramedical manifestations (cosmetology, beauty centres etc.). Thus, acne is encountered in around 85% of the subjects of the second decade of life (1,4,6), androgenetic alopecia may affect up to 50% of the women below 50 years old, while hirsutism will affect 5-15% of the total of the women (2,10) and more than 40% of those at menopause (4). Being considered as the second cause of hyperandrogenism, the congenital adrenal hyperplasia (CAH) with delayed debut has a prevalence of 1,4-4%(11). 21-hidroxilasis deficit is the most frequent cause