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The enzymes that facilitate phosphate and sulfate hydrolysis are among the most proficient natural catalysts known to date. Interestingly, a large number of these enzymes are promiscuous catalysts that exhibit both phosphatase and sulfatase activities in the same active site and, on top of that, have also been demonstrated to efficiently catalyze the hydrolysis of other additional substrates with varying degrees of efficiency. Understanding the factors that underlie such multifunctionality isdoi:10.1021/acs.biochem.6b00297 pmid:27187273 pmcid:PMC4899807 fatcat:odxkx4rrhbfdxhsak3g75ai3si