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Phosphorylation of histone H3 protein at serine 10 is an important step in chromatin remodeling during transcriptional transactivation. IB kinase-␣ (IKK-␣) and Mitogen-and Stress-activated protein Kinases 1 and 2 (MSK1/2) have been shown to play key roles in the transcriptional regulation of immediate early genes such as c-fos. Interestingly, IKK-␣ and MSK1/2 have also been implicated as histone H3-Ser 10 kinases. In this work, we have shown that MSK1/2 are required for epidermal growth factordoi:10.1074/jbc.m513333200 pmid:16517600 fatcat:cpghxsvtofavxc5ajkasoxx3ni