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Distinct transcriptional control in major immunogenetic subsets of chronic lymphocytic leukemia exhibiting subset-biased global DNA methylation profiles
2012
Epigenetics
These first authors contributed equally to this work. ‡ These senior authors contributed equally to this work. cell receptors (BcRs). 3-9 These findings have strongly implied a role for antigen selection in CLL development. Recent studies have also revealed an important association between stereotyped BcRs and clinical outcome for certain subsets. 6,10,11 For instance, subset #1 cases typically express heavy chains encoded by one of the IGHV1/5/7 clan genes with a highly homologous heavy
doi:10.4161/epi.22901
pmid:23154584
pmcid:PMC3528698
fatcat:nno3utmlfne2zdyagyope6eiva