Distinct transcriptional control in major immunogenetic subsets of chronic lymphocytic leukemia exhibiting subset-biased global DNA methylation profiles

Meena Kanduri, Millaray Marincevic, Anna M. Halldórsdóttir, Larry Mansouri, Katarina Junevik, Stavroula Ntoufa, Hanna Göransson Kultima, Anders Isaksson, Gunnar Juliusson, Per-Ola Andersson, Hans Ehrencrona, Kostas Stamatopoulos (+1 others)
2012 Epigenetics  
These first authors contributed equally to this work. ‡ These senior authors contributed equally to this work. cell receptors (BcRs). 3-9 These findings have strongly implied a role for antigen selection in CLL development. Recent studies have also revealed an important association between stereotyped BcRs and clinical outcome for certain subsets. 6,10,11 For instance, subset #1 cases typically express heavy chains encoded by one of the IGHV1/5/7 clan genes with a highly homologous heavy
more » ... entarity determining region 3 (VH CDR3), in combination with kappa light chains encoded by IGKV1-39/1D-39. These patients carry unmutated IGHV genes and have poorer prognosis compared with non-stereotyped,
doi:10.4161/epi.22901 pmid:23154584 pmcid:PMC3528698 fatcat:nno3utmlfne2zdyagyope6eiva