The rise in Pantone-Valentine leucocidin (PVL) and gAMMA-haemolysin (Hlg) producing Enterococcus spp., among the people is a serious concern on evolution of antibiotic resistance. Recent reports suggested that the synergistic association of PVL toxin and necrotic lesions that lead to infections in skin and mucosa. To study the prevalence of Enterococcus isolated from the various clinical samples from both inpatient and out - patient department at a Tertiary care hospital. The resistance to

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... ne-Valentine leucocidin (PVL) and gAMMA-haemolysin (Hlg) is further tested by using E-test strips for gentamicin test showed 26.8% of isolated populations had resistance to cell wall active agents. In our study all the intermediately sensitive to vancomycin isolates were found to be vancomycin sensitive by both the Epsilometer test and automated Vitek 2 system. The minimum inhibitory concentration ranging from 0.5 - 4 ug/ml. Hence my study confirmed good activity of the vancomycin, linezolid and Teicoplanin against isolated Enterococci spp.