Internet Archive Scholar

DNA vaccine priming for seasonal influenza vaccine in children and adolescents 6 to 17 years of age: A phase 1 randomized clinical trial

Katherine V. Houser, Galina V. Yamshchikov, Abbie R. Bellamy, Jeanine May, Mary E. Enama, Uzma Sarwar, Brenda Larkin, Robert T. Bailer, Richard Koup, Myeisha Paskel, Kanta Subbarao, Edwin Anderson (+9 others)
2018 PLoS ONE  

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (1.6 MB)
https://web.archive.org/web/20190228063152/http://pdfs.semanticscholar.org/8dad/a71292282dac578713a1cfcb2f8a2362488a.pdf

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL. The file type is application/pdf.

Children are susceptible to severe influenza infections and facilitate community transmission. One potential strategy to improve vaccine immunogenicity in children against seasonal influenza involves a trivalent hemagglutinin DNA prime-trivalent inactivated influenza vaccine (IIV3) boost regimen. Methods Sites enrolled adolescents, followed by younger children, to receive DNA prime (1 mg or 4 mg) intramuscularly by needle-free jet injector (Biojector), followed by split virus 2012/13 seasonal
more » ... V3 boost by needle and syringe approximately 18 weeks later. A comparator group received IIV3 prime and boost at similar intervals. Primary study objectives included evaluation of the safety and tolerability of the vaccine regimens, with secondary objectives of measuring antibody responses at four weeks post boost by hemagglutination inhibition (HAI) and neutralization assays.
doi:10.1371/journal.pone.0206837 fatcat:p6btt2eakjbetltw72upsmipga
DOAJ
Citation

Katherine V. Houser, Galina V. Yamshchikov, Abbie R. Bellamy, Jeanine May, Mary E. Enama, Uzma Sarwar, Brenda Larkin, Robert T. Bailer, Richard Koup, Myeisha Paskel, Kanta Subbarao, Edwin Anderson, David I. Bernstein, Buddy Creech, Harry Keyserling, Paul Spearman, Peter F. Wright, Barney S. Graham, Julie E. Ledgerwood, the VRC 702 study team, Nagendra R. Hegde. "DNA vaccine priming for seasonal influenza vaccine in children and adolescents 6 to 17 years of age: A phase 1 randomized clinical trial." PLoS ONE 13.11 (2018) e0206837