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Mitochondrial-nuclear heme trafficking is regulated by GTPases that control mitochondrial dynamics
[article]
2019
bioRxiv
pre-print
Heme is an essential cofactor and signaling molecule. All heme-dependent processes require that heme is trafficked from its site of synthesis in the mitochondria to hemoproteins in virtually every subcellular compartment. However, the mechanisms governing the mobilization of heme out of the mitochondria, and the spatio-temporal dynamics of these processes, are poorly understood. To address this, we developed a pulse-chase assay in which, upon the initiation of heme synthesis, heme mobilization
doi:10.1101/539254
fatcat:kh6pq735rjdzdikqe6zdml5wim