Exploiting the borono-Mannich reaction in bioactive alkaloid synthesis

Stephen G. Pyne, Christopher W. G. Au, Andrew S. Davis, Ian R. Morgan, Thunwadee Ritthiwigrom, Arife Yazici
2008 Pure and Applied Chemistry  
We have demonstrated that the borono-Mannich reaction is a versatile and efficient reaction for the diastereoselective preparation of chiral 1,2-amino alcohols. These Mannich products are valuable starting materials as shown in this report by the synthesis of bioactive polyhydroxylated pyrrolizidine and indolizidine alkaloids. Initial studies, directed at the more complex
doi:10.1351/pac200880040751 fatcat:zguc2bqhkbd6dnj7fa2n57bu2i