The Comparison of Carotid Artery Intima-media Thickness and Plaque Characteristics between Patients with ST-elevation Myocardial Infarction and Coronary Artery Chronic Total Occlusion

Sun Young Choi, Jong Sung Park
2015 Biomedical Science Letters  
ST-segment elevation myocardial infarction (STEMI) and chronic total occlusion (CTO) of coronary artery are wellknown atherosclerotic vascular diseases. However, the difference of intima-media thickness and plaque characteristics of carotid arteries between STEMI and CTO patients were not directly compared in previous studies. Medical records of a total of 158 (101 STEMI, 57 CTO) patients, who underwent carotid artery ultrasonography, were selected for the analysis. The baseline
more » ... ine characteristics, ultrasonography findings, and clinical outcomes of the two groups were compared. The prevalence of hypertension, diabetes mellitus, and dyslipidemia was significantly higher in CTO patients. Carotid intima-media thickness (0.97 ± 0.13 vs. 0.78 ± 0.17 mm, P < 0.0001) and number of plaques (2.2 ± 1.0 vs. 1.7 ± 1.2, P < 0.0001) were greater in CTO than STEMI patients. Multiple (≥ 3) or echogenic plaques were more frequently observed in CTO patients. During the median follow-up duration of 27 months, major adverse cardiovascular events occurred in 31% of CTO and 14% of STEMI patients (P = 0.008). We found that, compared with STEMI, CTO patients have higher burden of carotid artery atherosclerosis associated with more comorbid diseases and poor clinical outcomes.
doi:10.15616/bsl.2015.21.4.198 fatcat:wlcr2lb3wra2dkfgw6s2cigh3u