The main goal of the periodontal therapy is the regeneration of the affected periodontal structures and achievement of stable periodontal attachment. The contemporary statement regarding the effectiveness of the periodontal therapy is that healing results with more coronal level of the connective tissue attachment are associated with better long term stability. Aim: Evaluation of the effectiveness of treatment of severe chronic periodontitis with additional target antibiotic administration in

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... mparison with the therapy with adjunctive antimicrobial combination amoxicillin+ metronidazole and conventional mechanical periodontal treatment regarding the mean clinical attachment gain, reduction of the attachment loss extent and the variations of the attachment level in sites with initial CAL from 1-2mm, from 3-4mm and above 5mm. Results: In all study groups mean clinical attachment gain has been achieved after the non-surgical periodontal therapy. In the group with target antibiotic administration the highest reduction of periodontal sites with CAL above 5mm is reported.