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Identification of ligand-specific G-protein coupled receptor states and prediction of downstream efficacy via data-driven modeling
[article]
2020
bioRxiv
pre-print
G protein-coupled receptors (GPCRs) shift between inactive non-signalling states and active signalling states, to which intracellular binding partners can bind. Extracellular binding of ligands stabilizes different receptor states and modulates the intracellular response via a complex and not well understood allosteric process. Despite the recent advances in structure determination and spectroscopy techniques, a comprehensive view of the ligand-protein interplay remains a challenge. We derived
doi:10.1101/2020.07.06.186601
fatcat:w4fwbh3p7nhm5eurbwn4wml3fu