Calcitonin Reduces Corticosterone-Induced Muscle Proteolysis

Kouji HIGUCHI, Kunioki HAYASHI, Yusuke SHIMOOZAKI, Akira OHTSUKA, Yuichiro TOMITA
1995 Journal of Nutritional Science and Vitaminology  
Two-experiments were conducted to clarify the effect of calcitonin (CT) on growth, muscle protein breakdown, plasma corticos terone (CTC) concentration and urinary calcium excretion in young growing rats treated with CTC. Rats received hormonal treatments for 6 days (Experiment 1) or 24h (Experiment 2). Dose levels of CTC were 10 mg and 5mg/100g body weight/day in experiment 1 and 2, respectively, and that of CT was 100m unit/100g body weight/day in both experiments. Muscle protein degradation
more » ... rotein degradation was evaluated by urinary Nr-methylhistidine excretion. CT increased 24-h urinary calcium excretion but not 6-day calcium excretion. CTC markedly inhibited growth, accelerated muscle protein degradation and increased calcium excretion in both experiments. However, very interestingly, CT minimized CTC-induced muscle proteo lysis, and normalized the CTC-induced decrease in urinary calcium excretion. Furthermore, CT decreased the CTC-induced increase in the plasma CTC concentration. The present observations indicate that CT reduces CTC-induced muscle protein breakdown by reducing the plasma CTC concentration and that increased urinary calcium excretion due to CT treatment may also play a role in reducing CTC-induced muscle protein breakdown.
doi:10.3177/jnsv.41.545 fatcat:5gac2rmcrrh4pexotvtl6oownq