Natural bioactive compounds are better than synthesised chemical compound. As the overuse & misuse of certain antibiotics have led to adverse environmental effects and raised public concerns. Bacteria are considered as the most common source of natural bioactive compounds. In the present study isolated bacterial strain Bacillus cereus NSD 10072 had been used. Bacterial strain has antimicrobial activity against both Gram positive and Gram negative bacteria which act as common human pathogens.

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... ferent low cost substrate was used and best growth of the bacterium was found in animal feed supplemented with minimal media. Total organic carbon, Protein and total solid content of substrate used were found 0.0340%, 13.363µg/ml and 0.0466% respectively. Metal ions Fe, Zn, Cd, Pb and Cu were found in the substrate by using atomic absorption spectrum. For the isolated strain growth conditions were optimised using response surface methodology. Maximum growth and antibacterial activity was obtained by bacterial strain at 34°C after 54 hrs and at 160 rpm. Hence, the isolated strain is a potent source of antimicrobial activity and can be used in the field of food, feed, cosmetic and preservative industries.