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A genetically encoded biosensor reveals location bias of opioid drug action
[article]
2018
bioRxiv
pre-print
Opioid receptors (ORs) precisely modulate behavior when activated by native peptide ligands but distort behaviors to produce pathology when activated by non-peptide drugs. A fundamental question is how drugs differ from peptides in their actions on target neurons. One way that drugs can differ is by imposing selective effects on the conformational equilibrium of individual ORs. We wondered if drugs can also impose selective effects on the location of OR activation in individual OR-expressing
doi:10.1101/254490
fatcat:ww5fssx5njfznlguyhtptuv6am