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A new approach modeling the fails in biological tissue is here proposed. Under the assumption that the cell membrane may be modeled, similarly as neo-Hookean materials, I develop the problem in the framework of nonlinear elasticity. I try to model the ice nucleation phenomenon when freezing and thawing occurs in cellular cryo-preservation. The generated surface of the ice seed can be either soft or wrinkled and, in the latter case a punch contact against the cell membrane take place.doi:10.15761/fgnamb.1000130 fatcat:jwsngyzuyzctnnx5fssqussn2a