Dissemination of Rat Cytomegalovirus through Infected Granulocytes and Monocytes In Vitro and In Vivo

B. W. A. van der Strate, J. L. Hillebrands, S. S. Lycklama a Nijeholt, L. Beljaars, C. A. Bruggeman, M. J. A. van Luyn, J. Rozing, T. H. The, D. K. F. Meijer, G. Molema, M. C. Harmsen
2003 Journal of Virology  
Citation for published version (APA): van der Strate, B., Hillebrands, J-L., Lijcklama a Nijeholt, S. S., Beljaars, L., Bruggeman, C. A., van Luyn, M., ... Harmsen, M. C. (2003). Dissemination of rat cytomegalovirus through infected granulocytes and monocytes in vitro and in vivo. The role of leukocytes in the in vivo dissemination of cytomegalovirus was studied in this experiment. Rat cytomegalovirus (RCMV) could be transferred to rat granulocytes and monocytes by cocultivation with
more » ... ed fibroblasts in vitro. Intravenous injection of purified infected granulocytes or monocytes resulted in a systemic infection in rats, indicating that our model is a powerful tool to gain further insight into CMV dissemination and the development of new antivirals.
doi:10.1128/jvi.77.20.11274-11278.2003 pmid:14512575 pmcid:PMC224975 fatcat:4qwhx65epbgwhaxt65og3stw4q