Myelin development in visual scene-network tracts beyond late childhood: A multimethod neuroimaging study [article]

Tobias W. Meissner, Erhan Genç, Burkhard Mädler, Sarah Weigelt
2019 bioRxiv   pre-print
AbstractThe visual scene-network—comprising the parahippocampal place area (PPA), retrosplenial cortex (RSC), and occipital place area (OPA)—shows a prolonged functional development. Structural development of white matter that underlies the scene-network has not been investigated—despite its potential influence on scene-network function. The key factor for white matter maturation is myelination. However, research on myelination using the gold standard method of post-mortem histology is scarce.
more » ... n vivo alternatives diffusion tensor imaging (DTI) and myelin water imaging (MWI) so far report broad-scale findings that prohibit inferences concerning the scene-network. Here, we combine MWI, DTI tractography, and fMRI to investigate myelination in scene-network tracts in middle childhood, late childhood, and adulthood. We report increasing myelin from middle childhood to adulthood in lRSC-lOPA, rPPA-rRSC, and lPPA-lRSC tracts. Moreover, tracts connecting the OPA to the key input regions hippocampus, V1, and V2 showed myelin increases beyond late childhood. Our findings indicate that structural development coincides with functional development in the scene network, possibly enabling structure-function interactions.HighlightsMyelin in intrahemispheric scene-network tracts increases beyond late childhoodTracts connecting OPA and hippocampus, V1, and V2, also show prolonged myelinationDiffusion tensor imaging parameters do not mirror myelin water fraction results
doi:10.1101/662809 fatcat:6e2p357cbrasbi7pkczyfefpsi