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Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines sporadic ALS using published data (3, 4). We found significant differential expression of NRP2, encoding neuropilin 2, in primary fibroblastsdoi:10.31219/osf.io/s5bnv fatcat:gfac2sl5hvhv3a2im3kgv5apca