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TGFβ2-Induced Changes in Human Trabecular Meshwork: Implications for Intraocular Pressure
Investigative Ophthalmology and Visual Science
PURPOSE. Transforming growth factor (TGF)-␤2 levels are elevated in glaucomatous human aqueous humor. TGF␤ is a cytokine that alters extracellular matrix (ECM) metabolism, and excess ECM has been proposed to increase aqueous outflow resistance in the trabecular meshwork (TM) of glaucomatous eyes. This study was undertaken to investigate effects of TGF␤2 on secretion of fibronectin and the protease inhibitor plasminogen activator inhibitor (PAI)-1 from human TM cell cultures and perfused humandoi:10.1167/iovs.05-1060 pmid:16384967 fatcat:e3p6sd5p65dvpj6ubwxhz6v2bq