We used the rabbit as an experimental model to elaluate the effect of chronic renai failure on testicular fullctioll . Thirtcen adu ] tniale rabbits underwent partial( two − thirds) nephrectumy . After three weeks the contralateral kidney was resected ( group A ) . Another six rabbits undcrwent a two stage sha 【 n − operatic )n ( group B ) . Three months after the secon 〔 l surgical procedure the rabbits in group A showed significantly lower 、 厂 alues in sperm concentration and motility of

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... samples , concentration of testosterone ill peripheral serum , and binding capac − ity of androgen − binding protcin in testicular cytosols conipared with anilnals in groul)s B ( Student ' s t − test ;p く ( ) 、 05 ) . In c 〔〕ntrast , the values of serum LH and FSH levels , and serum creatlnine alld urea levels were significantly higher in group A than in group B 、 The curre 囗 t findings shuw a dcficiency in spermatogenic process and epididymal sperm matu − ration in uremic rabbits attributable to defects ill